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This process releases stored iron into the LIP, thereby increasing the cells susceptibility to ferroptosis (48, 49)
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It is related to the binding of selenoprotein-P to the endothelium in sepsis, to the protein extravasation at the early phase of sepsis, and to downregulation of selenoprotein-P liver synthesis [33]
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While glutathione supplementation is generally considered safe and well-tolerated, some individuals may experience mild side effects such as stomach upset or allergic reactions
These disorders are attributed to glutathione depletion in the gamma-glutamyl cycle [13], the mechanism for which is shown in Fig
