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Second, analytical weighing errors during vial filling accumulate across production batches

The overall survival was also affected with HR for premature death of 1.06 (1-1.12) for all-cause mortality and HR 1.21 (CI 1.05-1.38) for CVD

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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

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