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Nausea is the most frequently experienced side effect, potentially affecting a significant proportion of patients, particularly during the initial weeks of therapy and during dose escalation periods
The renal or extrarenal expression of 1--hydroxylase (CYP27B1) enzymatic action converts 25(OH)VD 3 to an active metabolite 1,25-dihydroxy vitamin D 3 (1,25(OH) 2 VD 3) 13
And they have moved through distinct eras: discovery in the 1980s, broad development in the 2010s, rapid growth and consumerization in the early 2020s, and the current phase, which we believe will be defined by innovation and expansion
By targeting three pathways, it suppresses appetite, improves glucose control and boosts calorie burning more effectively than current simple or dual agonists
2021;6:eabf7570
3,6,7 Evidence supporting the use of cyclosporine and botulinum toxin A is limited, and currently neither of these treatment options is approved by the FDA
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