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Wheeler, D., Bandaru, V
Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)
Under oxidative stress, characterized by elevated reactive oxygen species (ROS), GSH in its reduced form is increasingly converted into its oxidized form, GSSG
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The inclusion of a glutathione-responsive crosslinker with disulfide bonds ensures precise cleavage and release of methacrylate-temozolomide and siPKM2 in the high glutathione milieu characteristic of GBM cells
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