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Third, HF-specific outcomes such as functional capacity, quality of life, congestion burden, and recurrent hospitalization have been inconsistently reported

GLP-1s work through systemic signaling: brain appetite circuits, gut motility, pancreas, liver-facing metabolic changes, and for tirzepatide/retatrutide, additional incretin and glucagon-receptor effects

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It helps to protect cells from free radical damage, neutralizes toxins, and aids in the production of other antioxidants like vitamins C and E

It directly antagonizes the action of both GHRH and ghrelin receptor agonists