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Most common adverse events at all doses: Nausea (15-30%, dose-related) Vomiting (5-15%) Decreased appetite (~20%) Constipation (5-12%) Cagrilintide-specific notes: A 2025 Bayesian network meta-analysis of incretin-based therapies reported cagrilintide had one of the lowest GI odds ratios across the studied compound class

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Those results require sustained caloric deficits of 500-750 calories per day driven by appetite suppression

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