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doi:10.1089/ars.2010.3275

Here is an honest look at where the science stands as of early 2026: Animal studies are promising

The classification also does not take into account heterozygosity, which results in a wider spread of residual enzyme activity, as well as the effect of compounding mutations which has been shown to synergistically decrease the catalytic activity and/or protein stability (34)

Transient kinetic analysis of hydrogen sulfide oxidation catalyzed by human sulfide quinone oxidoreductase