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Mice were treated with cotadutide, liraglutide, g1437 or liraglutide+g1437 at equimolar dosing (10 nmol/kg, SC, QD for 42 days) compared to vehicle

It also slightly binds to MC-3R receptors responsible mostly for appetite control and energy regulation

Genet 153B , 12981304 (2010)

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Thus, approaches to prevent loss of lean mass, when used in combination with weight-loss therapies which suppress appetite and cause caloric restriction, could provide important benefits