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37 , e99753 (2018)
Conditions like pernicious anaemia (an autoimmune disorder where your body cant absorb B12 from food), certain stomach conditions, medications that reduce stomach acid, or even gastrointestinal surgeries (like weight loss surgery) can prevent your body from properly taking in B12, even if youre getting enough in your diet
GLP-1s may modulate gut microbiota and target immune cells in the brain and in the gut to reduce body wide inflammation
AMPK downstream of GLP-1 can rapidly inhibit PARP activity and reduce its ability to regulate downstream genes (Gongol et al., 2013
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To realize their full therapeutic potential, future research must rigorously address several critical dimensions, which collectively form a roadmap for the field
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