doi:10.1038/srep31599 pmid:27554391 Hayashi S, McMahon AP (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
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Studies have documented MC receptor binding at all five subtypes, with particular focus on MC1R-mediated pigmentation responses and MC4R-mediated CNS pathway modulation in rodent models
10.1016/S0140-6736(08)60694-7 8
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First, cancer was not a primary endpoint in most included trials, which may have led to underreporting or misclassification