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In conclusion, the repolarization of tumor-promoting M2 TAMs to M1-type TAMs that kills tumors is a major strategy to reverse immunosuppressive TME to anti-tumor TME by influencing TAMs, and a variety of nanodrug delivery systems have been developed, such as iron-based nanoparticles, nanoparticles loaded with TLR agonists, and nanoparticles loaded with signaling pathway inhibitors or activators

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity