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273 In a humanized mouse model with p53 codon 72 variants fed a high-fat diet (HFD), mice with the p53 R72 variant exhibited more severe glucose intolerance and obesity than did mice with the p53 P72 variant

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J Neurosci 34:70277042

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Tendinopathy & Ligament Support: It is highly effective at modulating the fibroblast activity in tendons and ligaments, promoting the rapid remodeling of collagen fibers following mechanical overload or injury

In the pivotal STEP 1 clinical trial, participants who received weekly semaglutide injections lost an average of 14.9% of their body weight over 68 weeks , compared with 2.4% in the placebo group (study in the New England Journal of Medicine )