doi: 10.1007/s10067-014-2517-2 PMCID: PMC3962576 The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain Jarred Younger, Luke Parkitny, and David McLain Curr Rheumatol Rev
The addition of lipoic acid further increased improvements in both clinical symptoms and NCV
A prospective cohort study involving 266 elderly adults treated with epithalamin (the parent compound from which Epithalon was derived) over 2-3 years with subsequent 4-5 year follow-up demonstrated mortality reduction of 28% overall, with a 2-fold decrease in cardiovascular disease-specific mortality
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