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FIGURE 3 TABLE 3 Overview of endogenous AT and their proposed mechanisms of action

Areas of investigation include nitric oxide (NO) signaling, vascular endothelial growth factor receptor 2 (VEGFR2)-associated angiogenesis, cellular survival pathways, and vascular remodeling

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Exendin-4 has been shown to reduce advanced glycation end product (AGE)-induced interleukin (IL)-6 and TNF- production, the expression of receptor for AGE (RAGE), and cell death in mesangial cells (Wang et al., 2014)

Potential Benefits As NAD+ is present in every cell and involved in almost every process, the potential benefits of NAD+ Therapy (and supplementation with NAD+ precursors) are wide-ranging

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