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Nausea, diarrhea, vomiting, constipation, and abdominal pain mostly early, mostly at each dose step-up, and mostly transient as the gut adapts

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192 ATR inhibitors (e.g., BAY1895344) demonstrate promising activity in DDR-deficient tumors and are undergoing clinical evaluation across solid tumor types

The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

doi: 10.1016/j.gene.2020.144488 142 SalehiSAdeshinaIChenHZirkinBRHussainMAWondisfordFet al

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