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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines
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Do not shake swirl gently
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Accepted clinical thresholds prioritize BMI and related conditions: a BMI 30 typically meets criteria for pharmacologic therapy, while a BMI 27 with qualifying comorbidities may also be eligible
10.3390/nu7115475 21
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