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Schfer et al., Early efforts to understand the regulation of glutathione biosynthesis in plants focused on substrate availability, feedback inhibition, and transcriptional control with more recent studies investigating post-translational modifications (Yi et al., Arabidopsis suspension cells transcriptional up-regulation of GCL in response to various oxidative stresses was not observed, even though both GCL activity and cellular glutathione levels increased (May et al., Localization of Glutathione Synthesis in Plants The localization of GCL and GS plays a major role in the biosynthesis of glutathione

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