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This study is significant for several reasons

Pertanto in questi soggetti la glicemia deve essere controllata regolarmente per poter tempestivamente provvedere, se necessario, allaggiustamento della terapia ipoglicemizzante (vedere paragrafo 4.4)

First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)

Kalia LV, Lang AE