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Ren G, Xue P, Wu B, Yang F, Wu X, Ren G, et al
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Metformin primarily reduces glucose production in the liver, while GLP-1s have broader effects on appetite, gastric emptying, and insulin/glucagon balance
92 Cardiovascular Outcome Trials of GLP-1RAs in Patients with HFpEF In contrast to its use in patients with HFrEF, GLP-1 RA use in patients with HFpEF is associated with significant improvements in symptoms, weight loss and enhanced quality of life
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