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Triple-hormone-receptor agonist retatrutide for obesity: a phase 2 trial

Anjum, S

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The typical clinical manifestation is bowel obstruction in a critically ill patient becoming febrile, with signs of acute cholecystitis, dehydration, and aspecific biochemical abnormalities such as leukocytosis, elevated aminotransferase levels, electrolyte imbalance due to dehydration, and concomitant heart, pulmonary, and metabolic comorbidities [179]

Oral dosing requires 15-20 higher amounts to achieve equivalent plasma levelsif achievable at all