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Pickart's foundational work and subsequent studies on copper peptides and wound closure point to upregulation of matrix metalloproteinases, the enzymes responsible for remodeling collagen into organized structure during repair, rather than the disorganized collagen deposition that produces visible scarring
Its sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, with a molecular formula of C 62 H 98 N 16 O 22 and a molecular weight of 1,419.53 g/mol (CAS 137525-51-0)
(PubMed) Squire L, Berg D, Bloom F, du Lac S, Ghosh A, Spitzer N
Shingai, M
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
The tradeoff is larger injection volumes at higher doses
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