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In chronic pain states, TRPV1 channels are upregulated in nociceptive neurons, which lowers stimulation thresholds and increases pain perception, as reported in hyperalgesia or allodynia 21
Mechanisms of Ageing and Development
Beyond altering neuronal transcription, neuronal activity also has consequences on gene expression in nearby non-neuronal cells
Always consult with a qualified healthcare professional before using any peptide or supplement
Lancet (2012) 379:125668
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