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The chief activator of AMPK is the serine-threonine tumor suppressor kinase LKB1, which contributes to phosphorylation of AMPK to activate energy sensors (235, 238)
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Many of these side effects are known or were previously known by manufacturers, but were not displayed, under disclosed, delayed in disclosed, or the risks were otherwise minimized
The most frequently reported side effects are gastrointestinal in nature , with dose-dependent rates that vary by indication
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