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Loading protocol (optional, not generally recommended for people with type 2 diabetes): 20 grams per day, divided into 4 doses of 5 grams each Duration: 57 days This rapidly saturates muscle creatine stores but may increase the risk of gastrointestinal side effects and water retention Maintenance dose (recommended approach for people with type 2 diabetes): 3 grams per day as a single dose This achieves muscle saturation more gradually (typically within 34 weeks) Generally better tolerated and equally effective over time Allows for careful monitoring of any effects on blood glucose levels or medication requirements For people with diabetes, starting with 3 grams daily without a loading phase is the most prudent approach, as it minimises potential side effects and allows for careful monitoring

Warnings Hypersensitivity Reactions Serious hypersensitivity reactions, including anaphylaxis, laryngeal edema, and bronchospasm have been reported following levocarnitine injection administration, mostly in patients with end stage renal disease who are undergoing dialysis

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PMID: 23868456

THIOCTIC ACID Thioctic acid is an antioxidant