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Through neural pathways as well as via receptor-mediated effects, GLP-1 reduces postprandial hyperglycemia by stimulation of insulin secretion, suppression of glucagon release, inhibition of gastric emptying and small intestinal peristalsis, and induction of satiety which limits meal size [17]

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The key message is that perceived changes in subjective effects don't necessarily indicate reduced therapeutic efficacy

Retatrutide: Phase 2 Trial The Phase 2 trial enrolled 338 adults with obesity

The FDA warning letter is a red flag for some people