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Description

Tirzepatide (Eli Lillys Mounjaro/Zepbound) is a dual GLP-1/GIP receptor agonist with four years of Phase 3 data, three FDA approvals, and a published cardiovascular outcomes trial

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Ozempic, which contains semaglutide as its active ingredient, has been associated with serious gastrointestinal problems, including gastroparesis (delayed stomach emptying) and pancreatitis

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[3],[4] In addition, the traditional role of metformin in the early management of T2D is not always appropriate if not tolerated or contraindicated (eg, eGFR 20-25 mL/min/1.73 m 2

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The cardiovascular effects of Wegovy have been extensively studied, with the SELECT trial demonstrating a significant reduction in major adverse cardiovascular events in patients with established cardiovascular disease, though this is not a current UK-licensed indication

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