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342 The tri-agonist lowered body weight in diet-induced obese mice by 26.6% after 20 days of treatment, whereas the GLP-1R/GIPR coagonist lowered body weight by 15.7%, and it was found that the action of the tri-agonist occurred in a dose-dependent manner

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therefore, we cannot confirm medication acquisition, adherence, or continuous exposure, and apparent switches may partly reflect treatment gaps, intermittent use, or reinitiation rather than deliberate within-class substitution

Stout J, De Vos D, Vergauwen B, Savvides SN (2012) Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold