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The endogenous ligand GIP results in full agonism of the mouse GIPR, and the AMG 133 murine surrogate fully antagonized native GIP (IC 50 = 4.1 nM) (Extended Data Fig
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doi:10.1007 Fuggle, N R et al
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This evidence, combined with earlier trials on people with type 2 diabetes, led the FDA to extend the indications for Wegovy
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