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Finally, although investigators often excluded individuals with any other systemic diseases (diabetes mellitus, abnormal lipid profile, cardiovascular, kidney and/or liver diseases) [1824, 2832, 3640, 61], the wash-out period (treatment free period before blood collection) was very variable (2 weeks - 6 months) [20, 21, 23, 27, 2932, 3640, 44, 59, 61]

They used a hydroquinone-induced vitiligo mouse model and human epidermal melanocyte cell lines (PIG1 and PIG3V)

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While phMRI and rsFC are agnostic with respect to the mechanism(s) of an opportunistic molecule like PEA the data can be used to make prediction about molecular and behavioral outcomes

Each strain must be rigorously evaluated to confirm the absence of pathogenic traits, such as the ability to cause infection or produce toxins (142)

If a dose is missed, it should be given within four days