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doi: 10.3389/fphys.2024.1352305 Received 08 December 2023 Accepted 31 January 2024 Published 20 February 2024 Volume 15 - 2024 Edited by Thomas William Lowder, Baptist Health Foundation, United States Reviewed by Alessandra Amato, University of Palermo, Italy Nicola Modugno, Mediterranean Neurological Institute Neuromed (IRCCS), Italy Updates Copyright 2024 Paterno, Polsinelli and Federico

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Because retatrutide has not yet received regulatory authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), it is not legally available for prescription in the UK outside of authorised clinical trials

No loading or cycling is needed with carnitine supplementation either

Why Physician Supervision Matters While peptides are often marketed online, using them without medical supervision is risky

Each phase lasts a minimum of four weeks