Cumulative loss typically reaches 12 to 18 pounds
Results can vary based on individual health, diet, and exercise
It enhances local NO production [88], protects against endothelial dysfunction, and inhibits plaque formation and thrombosis
However, the mechanisms by which fatty liver disease progresses to inflammatory conditions from concomitant obesity and alcohol consumption (here, termed the syndrome of metabolic and alcoholic fatty liver disease (SMAFLD)) are not fully known
In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]
Semaglutide and other GLP-1 medications have expanded far beyond their original diabetes indication