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Whilst this screen produced potential hit molecules, each compound failed to reconfirm in an orthogonal technique, binding to USP8 by either SPR or NMR, and this led us to further investigate the potential mode of inhibition of these compounds by a panel of different assays to determine if the hits were genuine

Abnormal early cleavage events predict early embryo demise: sperm oxidative stress and early abnormal cleavage

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Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer

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