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Acetylcarnitine also has potential regulatory effects on pain perception and emotion regulation by increasing the level of acetylated H3K27 bound to the Grm2 promoter through the epigenetic regulation of the type 2 metabotropic glutamate (mGlu2) receptor, as well as the acetylation of the NF-B p65 subunit by increasing the transcription of the Grm2 gene [40, 41]

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The authors acknowledge the support of Helmholtz Alliance ICEMED, the Helmholtz Initiative on Personalized Medicine iMed, the Helmholtz crossprogram topic Metabolic Dysfunction, the Alexander von Humboldt Foundation, the German Research Foundation (DFG) (SFB1123) and the European Research Council (AdG HypoFlam no

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