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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices 100 days, and significantly increased the median event-free survival relative to L-PAM alone
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The peptide enhances granulation tissue formation, re-epithelialization, and dermal remodeling through ERK1/2 signaling pathways
10 ml Ampullen
10.1158/0008-5472.CAN-07-0515 Cancer Res
10.3390/ijms13033145 Int
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