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A mutation in one of both genes can lead to a generalized MTP deficiency due to instability of the complex [141]

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As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner (49, 50) ( Figure 1D )

on polycystic ovary syndrome-induced mice, LC in the dosage of 500 mg/kg for every second day demonstrated a significant reduction in IL-6, MDA, and tumor necrosis factor- (TNF-) in the intervention group versus control after 28 days [23]

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Krishna Mohan S, Venkataramana G: Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with pregnancy induced hypertension