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de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, et al
These data support the gene expression data that showed upregulation of CART mRNA in the ARH following semaglutide administration, with simultaneous attenuation of hunger-stimulated increases in NPY and AgRP mRNA levels that were observed in the weight-matched controls
Some individuals are genetically programmed to store more fat in the abdominal region (android or "apple" shape), while others accumulate fat predominantly in the hips and thighs (gynoid or "pear" shape)
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