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Key questions including the existence of lactyl-CoA in vivo, the physiological relevance of non-enzymatic lactylation, and the identification of specific reader proteins must be resolved before lactylation can be fully established as a stable and universal regulatory mechanism

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The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process ( GLP-1 is one of the hormones responsible for the incretin effect, and exerts a wide variety of actions such as potentiation of glucose-stimulated insulin secretion, reduction of appetite, delay of gastric emptying and inhibit cell dysfunction (Vilsbll, 2009