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The p53(3KR) mutant, lacking acetylation due to lysine-to-arginine substitutions at three residues, decreases expression of SLC7A11 without affecting other p53 targets such as CDKN1A/p21 (involved in cell cycle progression) or BAX (involved in apoptosis)
Vitamin C also plays a regulatory role in hormone synthesis and neurotransmitter modulation
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He concluded that GLP-1 may act as neurotransmitter of the peptidergic nervous system in airways [111]
Phase 2 trials showed up to 24% body weight reduction at the highest dose, and Phase 3 data from the TRIUMPH program pushed that number even higher, reaching 28.7% in participants with obesity and knee osteoarthritis
Ann Indian Acad Neurol (2016) 19(2):17582.10.4103/0972-2327.182302 27 CuiYTakashimaTTakashima-HiranoMWadaYShukuriMTamuraYet al11C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression
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