My feeling is that if you use any smaller gauge of needle you risk damaging the surrounding tissue at the injection site
Nonetheless, the underlying reasons for the inconsistencies in the reported associations between T2DM and levels of plasma DPP-4 activity (lower, unaltered, higher) have not been adequately explained, although one study did suggest that it might be related to the populations studied, with changes only becoming evident once moderate or severe hyperglycaemia becomes established (68)
Wright AK, Carr MJ, Kontopantelis E, Leelarathna L, Thabit H, Emsley R, et al
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They don't cause photosensitivity like retinol , so morning application seems safe