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In contrast, multilamellar vesicles, with multiple concentric bilayers, may exhibit reduced loading efficiency due to restricted accessibility and lower available surface area per unit volume

Unlike IV infusion, subcutaneous administration eliminates the flushing, nausea, and chest tightness that IV protocols can produce when infused too rapidly

Cell Physiology 292 (6), C1993C2003

Mutations in these enzymes may alter their activity and play a role in the chemoresistance process