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In some healthcare systems, a doctor may train a patient or caregiver to administer intramuscular injections at home, but this must only be done under explicit medical guidance and with clear instructions on dose, technique, and disposal of sharps

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Concurrent administration of pyridoxine with these medications has been reported to lower their therapeutic levels, so monitoring and dosage adjustments of the anticonvulsant might be required if high-dose vitamin B is given

TRIUMPH-4: 8.8% at 9 mg, 20.9% at 12 mg

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