Timeline: High-dose results won't be available until 2028+, well after standard-dose approval
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The current findings are novel and need to be replicated, but provide initial evidence for the notion that biological processes related to cellular protection are involved in the response to a psychosocial intervention for anxiety and are also potentially useful for treatment prediction
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these were bile acid metabolites such as cholate and chenodeoxycholate, lipid metabolites such as arachidonic acid, C16:0-LPC, C18:0-SM, docosapentaenoate, adrenic acid and stearoyl ethanolamide, metabolites involved in the metabolism of protein or amino acids, such as imidazole propionate, ADMA and creatine, and active metabolites or neurotransmitters such as the n-acetylputrescine, diacetylspermine, malonate
Figure 1: Changes in A) sociability index, B) social novelty index, C) # USVs evoked, D) % marbles buried, E) grooming time in seconds between control mice and mice treated with MT-II Finally, the study explored differences in oxytocin receptor expression in the brains of MIA mice compared to normal C57BL/6J mice
