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The decision to escalate should be based on weight loss trajectory, appetite control , and side effect profile

Others notice that with decreased appetite, its simpler to choose workouts supporting foods, such as lean proteins and fresh vegetables

This improves overall glycemic control

Important safety note for people with diabetes: If you are taking insulin or a sulfonylurea alongside any investigational glucose-lowering therapy, improvements in blood glucose control may increase the risk of hypoglycaemia

PMID 15950558

A patient who loses 60 pounds over 18 months on tirzepatide will likely experience less hair impact than one who loses 60 pounds in 6 months through a very low calorie diet, even though neither used surgery