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These drugs also activate GLP-1 receptors in the hypothalamus, which increases the release of anorexigenic peptides like pro-opiomelanocortin while reducing the release of orexigenic peptides like neuropeptide Y and agouti-related peptide

Clinical trials are designed around percent body weight reduction, achievement of predefined thresholds such as 10 or 15 percent loss, and improvements in obesity-related comorbidities

What to Know About Potential Side Effects Like any medication, semaglutide has potential side effects

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Ozempic and Wegovy both have the same main ingredient, known as semaglutide