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Initiation of a GLP-1 receptor agonist was associated with reduced risk of composite endpoint of all SUDs (hazard ratio 0.86 (0.83 to 0.88), NRD 6.61 (7.95 to 5.26)) (fig 3, fig 4 and supplementary table S6)

And perhaps most importantly, recalibrate your tolerance expectations

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The study suggests that strategies targeting the opioid system, both behaviorally and pharmacologically, could be important in addressing the obesity epidemic

N., Vander Veur, S

In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain