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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen
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Patients with severe deficiency may need more frequent injections initially, while those using B12 for wellness optimization may maintain results with monthly treatments
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One is a raloxifene-loaded drug-eluting insert for intrauterine administration has been tested in animal models
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