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Serious Complications (Very Rare): Extremely rare but possible severe side effects can include congestive heart failure in individuals with certain heart conditions, or polycythemia vera (a blood disorder)

Administration of fibroblast growth factor-21 (FGF21) and analogues and antibodies that exhibit agonism of the fibroblast growth factor receptor 1 (FGFR1)Klotho beta (KLB) receptor complex can reduce body weight, liver fat, insulin resistance and blood glucose in animal models of obesity and diabetes, and initial clinical studies have encouraged further interest [77]

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In animal studies, semaglutide was associated with an increased risk of thyroid tumours

Dose changes need medical guidance because too little support may lead to appetite rebound, while too much can increase side effects or make nutrition harder