The capacity for GSH synthesis is insufficient to maintain GSH concentrations when tissues are exposed to certain drugs or their metabolites (e.g., acetaminophen), redox cycling compounds (e.g., menadione), peroxides (e.g., tertbutyl hydroperoxide), X-rays, or ultraviolet radiation
This slower transit time allows the intestines to absorb more water from the stool, resulting in firmer and drier stools that may be difficult to pass
These compounds are already poorly absorbed under normal conditions, which is why they cause gas and bloating for many people even without medication
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Any appetite effects reported are likely subtle and inconsistent
In functional medicine, the initial focus is on controlling the inflammation, decreasing immune dysregulation, and reducing auto-immune activation