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for some [dulaglutide (Marso et al., 2016) and semaglutide (Marso et al., 2017)], the CVOTs also confirmed a cardiovascular benefit and eventually led to the approved use of these GLP-1 RAs to reduce cardiovascular risk in people with type 2 diabetes and established CVD or at high cardiovascular risk (Sattar et al

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Insights into the early use of oral semaglutide in routine clinical practice: the IGNITE study

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However, its prudent to start slow, perhaps with around 50mcg once a week