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Osteoarthritis: While primarily a wear-and-tear condition, the inflammation caused by cartilage breakdown can lead to joint and back pain

Major Criteria Congenital multiple contractures, characteristically adduction-flexion contractures and/or talipes equinovarus (clubfoot) Characteristic craniofacial features, which are evident at birth or in early infancy Characteristic cutaneous features including skin hyperextensibility, easy bruisability, skin fragility with atrophic scars, increased palmar wrinkling Minor Criteria Recurrent/chronic dislocations Pectus deformities (flat, excavated) Spinal deformities (scoliosis, kyphoscoliosis) Peculiar fingers (tapering, slender, cylindrical) Progressive talipes deformities (valgus, planus, cavum) Large subcutaneous hematomas Chronic constipation Colonic diverticula Pneumothorax/ pneumohemothorax Nephrolithiasis/cystolithiasis Hydronephrosis Cryptorchidism in males Strabismus Refractive errors (myopia, astigmatism) Glaucoma/elevated intraocular pressure Myopathic EDS (mEDS) If a person meets the diagnostic criteria for mEDS, genetic testing should be done to confirm the diagnosis

The authors would like to declare the following patents/patent applications associated with this research: JP 4627841, 5639759, 4609845, 4942001, 5283173, 4822272, 5633952, and 5715046

Obes Surg 30:48524859

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GHK-Cu Microneedling: Depths & Results GHK-Cu microneedling protocol with needle depths by goal, step-by-step instructions, the copper uglies warning, and results timeline.